Novel non-ionic surfactant proniosomes for transdermal delivery of lacidipine: optimization using 23factorial design andin vivoevaluation in rabbits
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چکیده
منابع مشابه
Novel non-ionic surfactant proniosomes for transdermal delivery of lacidipine: optimization using 2(3) factorial design and in vivo evaluation in rabbits.
CONTEXT Proniosomes offer a versatile vesicle drug delivery concept with potential for delivery of drugs via transdermal route. OBJECTIVES To develop proniosomal gel using cremophor RH 40 as non-ionic surfactant containing the antihypertensive drug lacidipine for transdermal delivery so as to avoid its extensive first pass metabolism and to improve its permeation through the skin. MATERIALS...
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The aim of the present study was to prepare, optimize and characterize ketoprofen proniosomes. The niosomes were prepared using a slurry method followed by in vitro evaluation after embedding the proniosomes-derived niosomes into a carbopol matrix. A central, composite Box-Wilson design was used for the optimization with the total lipid concentration (X1), surfactant loading (X2) and amount of ...
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Niosomes are nonionic surfactant vesicles that have potential applications in the delivery of hydrophobic and hydrophilic drugs. Permeation of a potent nonsteroidal anti-inflammatory, ketorolac, across excised rabbit skin from various proniosome gel formulations was investigated using Franz diffusion cells. Each of the prepared proniosomes significantly improved drug permeation and reduced the ...
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Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact or atopic dermatitis referred to Razi hospital.Materials and Meth...
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2016
ISSN: 1071-7544,1521-0464
DOI: 10.3109/10717544.2015.1132797